Oct 2020: EDM Data Dictionary and Release Notes+bms

Flatiron R Packages

We’ve released a new version (0.2.0) of our cohort selection R package, rwdplyr, that includes:

• Updates to the summarize_patient_biomarker_status to align with the recent guidance released in the related tutorial, including new select methods and arguments
• Warnings in derive_age_at_event if a negative age is calculated
• Helper functions count_rows and count_patients for sizing remote and local tables
• New summarize_and_apply_gap_rule to calculate patient activity and filter patients in a single function call
• More detail can be found in the release notes in the repository

If you do not have access to rwdplyr and would like to, please submit the form on this webpage and Flatiron will follow up with further information.

COVID Updates

We’ve updated the Impact of COVID-19 on Flatiron Datasets section of the Knowledge Center for August 2020, including an update to our monthly observations of trends seen in Flatiron EDMs (incorporating data through July 2020), as well as a short explanation of ICD codes relating to COVID-19 in Flatiron EDMs.

Small Cell Lung Cancer

As part of Flatiron’s broader efforts to refactor our LineofTherapy rules, we have added a new rule in the SCLC EDM, specifying that substitution of the following biosimilars will not advance line numbers:

• Bevacizumab, bevacizumab-awwb, bevacizumab-bvzr
• Rituximab, rituximab-abbs
• Trastuzumab, trastuzumab-anns, trastuzumab-dkst, trastuzumab-pkrb

  Diffuse Large B-Cell Lymphoma

  As part of Flatiron’s broader efforts to refactor our LineofTherapy rules, we have added a new rule in the DLBCL EDM, specifying that substitution of the following biosimilars will not advance line numbers:

  • Bevacizumab, bevacizumab-awwb, bevacizumab-bvzr
  • Rituximab, rituximab-abbs
  • Trastuzumab, trastuzumab-anns, trastuzumab-dkst, trastuzumab-pkrb

    Disease	Total EDM Patients (October 2020)	Academic Patients (October 2020)
    Advanced Non-Small Cell Lung Cancer	64553	6104
    Chronic Lymphocytic Leukemia	12236	895
    Advanced Head & Neck Cancer	7556	732
    Advanced Urothelial Carcinoma	9195	824
    Diffuse Large B-Cell Lymphoma	7180	1036
    Multiple Myeloma	11454	1512
    Metastatic Renal Cell Carcinoma	9152	1105
    Hepatocellular Carcinoma	6075	1569
    Early Breast Cancer	10029	1101
    Metastatic Colorectal Cancer	26512	2005
    Advanced Gastric/Esophageal Cancer	10443	992
    Small-Cell Lung Cancer	7350	506
    Metastatic Breast Cancer	23485	1732
    Advanced Melanoma	10418	1760